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| Status |
Public on Apr 13, 2020 |
| Title |
Early termination of a Phase 1 trial of tenofovir disoproxil fumarate intravaginal ring linked to inflammation |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Objective: To assess safety in women of tenofovir disoproxil fumarate (TDF) polyurethane intravaginal ring (IVR) when used continuously for 3 months by healthy, HIV-uninfected, sexually active women, as compared with a placebo intravaginal ring
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| Overall design |
Women were randomized in a 3:1 ratio to receive either TDF or a placebo IVR which was changed monthly for 3 months
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| Contributor(s) |
Keller MJ, Bosinger SE, Wood L, Billingsley JM, Ray L, Goymer J, Sinclair S, Spiegel HM, McGinn AP, Mugo NR, Marzinke MA, Frank B, Srinivasan S, Liu C, Atrio JM, Espinoza L, Anderson PL, Fredricks DN, Hendrix CW, Marrazzo J, Herold BC, Tharp GK |
| Citation(s) |
31320290 |
| Submission date |
Nov 19, 2018 |
| Last update date |
Apr 13, 2020 |
| Contact name |
Gregory K Tharp |
| E-mail(s) |
gktharp@emory.edu
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| Phone |
404-727-7797
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| Organization name |
Yerkes National Primate Research Center
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| Department |
Developmental and Cognitive Neuroscience
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| Lab |
Genomics Core
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| Street address |
954 Gatewood Dr
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| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30329-4208 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (47)
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| Relations |
| BioProject |
PRJNA506039 |
| SRA |
SRP169593 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE122702_Herold_normalized_readcounts.txt.gz |
5.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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