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| Status |
Public on May 20, 2019 |
| Title |
Transcriptome analysis of small molecule-mediated astrocyte-to-neuron reprogramming |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Human astrocytes can be efficiently reprogrammed into functional neurons in culture by the addition of four small molecules. RNA-seq was performed to assess transcriptome alterations at different time points to characterize the molecular mechanisms.
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| Overall design |
RNA profiles of small molecule-treated human astrocyte culture at 6 time points throughout reprogramming, 3 replicates each.
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| Contributor(s) |
Ma N, Yin J, Chen G |
| Citation(s) |
31231645 |
| Submission date |
Nov 19, 2018 |
| Last update date |
Aug 19, 2019 |
| Contact name |
Gong Chen |
| Organization name |
Penn State University
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| Street address |
Old Main
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| City |
University Park |
| State/province |
PA |
| ZIP/Postal code |
16802 |
| Country |
USA |
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| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
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| Samples (18)
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| GSM3478716 |
day 0 treatment, rep 1 |
| GSM3478717 |
day 0 treatment, rep 2 |
| GSM3478718 |
day 0 treatment, rep 3 |
| GSM3478719 |
day 1 treatment, rep 1 |
| GSM3478720 |
day 1 treatment, rep 2 |
| GSM3478721 |
day 1 treatment, rep 3 |
| GSM3478722 |
day 3 treatment, rep 1 |
| GSM3478723 |
day 3 treatment, rep 2 |
| GSM3478724 |
day 3 treatment, rep 3 |
| GSM3478725 |
day 5 treatment, rep 1 |
| GSM3478726 |
day 5 treatment, rep 2 |
| GSM3478727 |
day 5 treatment, rep 3 |
| GSM3478728 |
day 14 treatment, rep 1 |
| GSM3478729 |
day 14 treatment, rep 2 |
| GSM3478730 |
day 14 treatment, rep 3 |
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| Relations |
| BioProject |
PRJNA506035 |
| SRA |
SRP169589 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE122701_counts.txt.gz |
2.6 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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