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Series GSE122041 Query DataSets for GSE122041
Status Public on Nov 01, 2018
Title Gene expression profiles of isogenic single-cell derived clones of BRAF-mutated SK-MEL-5 melanoma cell lines
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We recently reported that single-cell derived isogenic subclones of SKMEL5 cells have differential initial sensitivity to BRAF-inhibitors. In order to probe differences among these subclones, we selected three subclones with unique drug responses: progressing (SK-MEL-5 SC10), stationary (SK-MEL-5 SC07), and regressing (SK-MEL-5 SC01) and performed RNASeq. This study examines differentially expressed genes (DEGs) among the subclones to identify the molecular basis for initial differences in drug sensitivity.
Overall design Transcriptomics analysis between single-cell derived isogenic subclones of BRAF-mutated melanoma cell line, SK-MEL-5
Contributor(s) Paudel B, Quaranta V
Citation(s) 29590606, 33060170
NIH grant(s)
Grant ID Grant title Affiliation Name
R01 CA186193 Quantitative Multiscale Imaging to Optimize Cancer Treatment Strategies Vanderbilt University Medical Center Vito Quaranta
U01 CA174706 Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast Cancer UNIVERSITY OF TEXAS AUSTIN Vito Quaranta
Submission date Oct 31, 2018
Last update date Sep 29, 2021
Contact name B Bishal Paudel
Organization name Vanderbilt University
Department Biochemistry
Street address 2220 Pierce Ave PRB447
City Nashville
State/province TN
ZIP/Postal code 37232
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (9)
GSM3453520 SC01_rep1
GSM3453521 SC01_rep2
GSM3453522 SC01_rep3
BioProject PRJNA503257
SRA SRP167389

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE122041_featureCounts_matrix.txt.gz 637.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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