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Series GSE121663 Query DataSets for GSE121663
Status Public on Oct 01, 2019
Title Role of iron in the regulation of the epithelial-to-mesenchymal transition (RNA-seq)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy1,2. Here, we characterize using RNA sequencing the mRNA levels changes occurring during EMT induced by epidermal growth factor in breast cancer MDA-MB-468 cells. 1. Nieto, M. A., Huang, R. Y., Jackson, R. A. & Thiery, J. P. EMT: 2016. Cell 166, 21–45 (2016). 2. Puisieux, A. & Brabletz, T. & Caramel, J. Oncogenic roles of EMT-inducing transcription factors. Nat. Cell Biol. 16, 488–494 (2014).
Overall design Analyses of 6 samples: (i) untreated (ii) EGF 72h. Experiment was performed in 3 independent biological replicates
Contributor(s) Sindikubwabo F, Servant N, Baulande S, Raphael R
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Submission date Oct 23, 2018
Last update date Jul 09, 2021
Contact name Nicolas Servant
Organization name Institut Curie
Street address 26 rue d'ulm
City Paris Cedex 05
ZIP/Postal code 75248
Country France
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (6)
GSM4517603 Untreated replicate 1
GSM4517604 Untreated replicate 2
GSM4517605 Untreated replicate 3
This SubSeries is part of SuperSeries:
GSE121664 Role of iron in the regulation of the epithelial-to-mesenchymal transition
BioProject PRJNA498058
SRA SRP166454

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121663_tablecounts_raw.csv.gz 737.8 Kb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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