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Series GSE121662 Query DataSets for GSE121662
Status Public on Oct 01, 2019
Title Role of iron in the regulation of the epithelial-to-mesenchymal transition (ChIP-seq)
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy. Here, we characterize using chromatin immunoprecipitation and Next Generation Sequencing the genome-wide H3K9me2 distribution occurring during EMT induced by epidermal growth factor in breast cancer MDA-MB-468 cells.
 
Overall design Analysis of 9 samples: (i)Input DNA to normalize samples; (ii) H3K9me2 Immunoprecipitated in untreated cells and (iii) H3K9me2 immunoprecipitated in EGF-treated cells. Experiment was performed in 3 independent biological replicates.
 
Contributor(s) Sindikubwabo F, Servant N, Baulande S, Raphael R
Citation(s) 32747755
Submission date Oct 23, 2018
Last update date Jul 09, 2021
Contact name Nicolas Servant
E-mail(s) Nicolas.Servant@curie.fr
Organization name Institut Curie
Street address 26 rue d'ulm
City Paris Cedex 05
ZIP/Postal code 75248
Country France
 
Platforms (1)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
Samples (22)
GSM3443099 A1014C05: H3K9me2_untreated-1
GSM3443100 A1023C13: H3K9me2_untreated-2
GSM3443101 A1023C23: H3K9me2_untreated-3
This SubSeries is part of SuperSeries:
GSE121664 Role of iron in the regulation of the epithelial-to-mesenchymal transition
Relations
BioProject PRJNA498059
SRA SRP166453

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121662_Input_EGF_merged.bw 148.2 Mb (ftp)(http) BW
GSE121662_Input_untreated_merged.bw 229.1 Mb (ftp)(http) BW
GSE121662_RAW.tar 1.6 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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