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Series GSE121589 Query DataSets for GSE121589
Status Public on Aug 30, 2019
Title Dissecting the Individual and Collective Regenerative Behavior of Muscle Stem Cells During Aging
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Genome binding/occupancy profiling by high throughput sequencing
Summary We utilize an integrative genomics approach (bulk RNA-Seq, ATAC-Seq) to show how Muscle Stem Cells (MuSCs) from distinct age groups (young and aged) are significantly altered during the regenerative response. Transcriptional landscapes during quiescence, activation, proliferation and differentiation from young and aged mice are profiled and chromatin accessibility is compared.
 
Overall design Bulk RNA-Seq and ATAC-Seq at timepoints 0, 1 day, 3 day, 5 day, day 7, and day 21 post-injury for both young and aged mouse MuSCs
 
Contributor(s) Shcherbina A, Aguilar C
Citation(s) 32726628, 38328131
Submission date Oct 22, 2018
Last update date Feb 15, 2024
Contact name Carlos Aguilar
E-mail(s) caguilar@umich.edu
Organization name University of Michigan - Ann Arbor
Department Dept. of Biomedical Engineering & Biointerfaces Institute
Lab NANO-OMIC-BIO-ENGINEERING-LAB
Street address 300 Pasteur Dr
City Ann Arbor
State/province MI
ZIP/Postal code 48109
Country USA
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (90)
GSM4140537 MuSC_d0_Young_bulkRNAseq_Rep1
GSM4140538 MuSC_d0_Young_bulkRNAseq_Rep2
GSM4140539 MuSC_d0_Young_bulkRNAseq_Rep3
Relations
BioProject PRJNA497842
SRA SRP166762

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121589_BatchesForMergedATACSeqPeakSet.txt.gz 311 b (ftp)(http) TXT
GSE121589_RAW.tar 40.8 Gb (http)(custom) TAR (of BIGWIG, NARROWPEAK, TAGALIGN)
GSE121589_ReadCountsForMergedATACSeqPeakSet.txt.gz 10.6 Mb (ftp)(http) TXT
GSE121589_bulkRNAseq.FPKM.tsv.gz 2.5 Mb (ftp)(http) TSV
GSE121589_bulkRNAseq.TPM.tsv.gz 2.6 Mb (ftp)(http) TSV
GSE121589_bulkRNAseq.batches.txt.gz 202 b (ftp)(http) TXT
GSE121589_bulkRNAseq.expected_count.tsv.gz 2.9 Mb (ftp)(http) TSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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