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Series GSE121141 Query DataSets for GSE121141
Status Public on Nov 20, 2018
Title A whole lifespan mouse multi-tissue DNA methylation clock
Organism Mus musculus
Experiment type Methylation profiling by high throughput sequencing
Summary Age predictors based on DNA methylation levels at a small set of CpG sites, DNAm clocks, have been developed for humans and extended to several other species. Three currently available versions of mouse DNAm clocks were either created for individual tissues or tuned towards young ages. Here, we constructed a robust multi-tissue age predictor based on 435 CpG sites, which covers the entire mouse lifespan and remains unbiased with respect to any particular age group. It can successfully detect the effects of several lifespan-modulating interventions on biological age as well as the rejuvenation effect related to the transition from fibroblasts to iPSCs. We have carried out comparative analyses of available mouse DNAm clocks, which revealed their broad applicability, but also certain limitations to the use of tissue-specific and multi-tissue age predictors. Together, these tools should help address diverse questions in aging research.
 
Overall design Examination of DNA methylation (RRBS) in liver, heart, lung and cortex in age groups ranging from 6 months to 30 months
 
Contributor(s) Meer MV, Gladyshev VN
Citation(s) 30427307
Submission date Oct 11, 2018
Last update date Mar 01, 2019
Contact name Vadim Gladyshev
E-mail(s) vgladyshev@rics.bwh.harvard.edu
Organization name BWH
Street address 77 avenue louis pasteur
City Boston
ZIP/Postal code 02115
Country USA
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (81)
GSM3426754 Br0603
GSM3426755 Br0607
GSM3426756 Br0608
Relations
BioProject PRJNA495834
SRA SRP165217

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE121141_RAW.tar 2.8 Gb (http)(custom) TAR (of COV)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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