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| Status |
Public on Jan 15, 2020 |
| Title |
Early Angiogenic Proteins Associated with High Risk for Bronchopulmonary Dysplasia and Pulmonary Hypertension in Preterm Infants |
| Organism |
Homo sapiens |
| Experiment type |
Protein profiling by protein array
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| Summary |
Introduction: Early pulmonary vascular disease in preterm infants is associated with the subsequent development of bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH), however, mechanisms that contribute to or identify infants with increased susceptibility for BPD and/or PH are incompletely understood. Therefore, we tested if changes in circulating angiogenic peptides during the first week of life are associated with the later development of BPD and/or PH. We further sought to determine alternate peptides and related signalling pathways with the risk for BPD or PH.
Methods: We prospectively enrolled infants with gestational age <34 weeks gestation and collected blood samples during their first week of life. BPD and PH were assessed at 36 weeks postmenstrual age. Samples were assayed for each of the 1121 peptides included in the SOMAscanTM technology, with subsequent pathway analysis.
Results: Of 102 study infants, 82 had BPD and 13 had PH. Multiple angiogenic proteins (PF-4, VEGF121, ANG-1, BMP10, HGF, ANG2) were associated with the subsequent diagnosis of BPD, and FGF-19, PF-4, CTAP-III and PDGF-AA levels were associated with BPD severity. Early increases in BMP10 was strongly associated with the late risk for BPD and PH.
Conclusion: We found that early alterations of circulating angiogenic peptides and others were associated with the subsequent development of BPD. We further identified peptides that were associated with BPD severity and BPD-associated PH, including BMP10. We speculate that proteomic biomarkers during the first week of life may identify infants at risk for BPD and/or PH to enhance care and research.
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| Overall design |
A prospective cohort study. Included 102 infants, with extracted blood samples. Protein profiles existing of 1121 peptides, have been acquired by SOMAscan technology.
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| Contributor(s) |
Arjaans S, Wagner BD, Mourani PM, Mandell EW, Poindexter BB, Berger RM, Abman SH |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 10, 2018 |
| Last update date |
Jan 15, 2020 |
| Contact name |
Sanne Arjaans |
| E-mail(s) |
s.arjaans@umcg.nl
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| Organization name |
University Medical Center Groningen
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| Street address |
Hanzeplein 1
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| City |
Groningen |
| ZIP/Postal code |
9700 RB |
| Country |
Netherlands |
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| Platforms (1) |
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| Samples (102)
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| Relations |
| BioProject |
PRJNA495631 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE121097_Supplementary_File_1.xlsx |
1.6 Mb |
(ftp)(http) |
XLSX |
| Processed data are available on Series record |
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