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Series GSE120987 Query DataSets for GSE120987
Status Public on Jul 16, 2019
Title COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling [ChIP-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We show that the COMPASS family histone methyltransferase co-factor ASH2L is required in NPCs proliferation and upper layer cortical projection neurons production and position. Deletion of ASH2L impairs trimethylation of H3K4 and transcriptional machinery specifically for subsets of Wnt-β-catenin signaling, disrupting their transcription and consequently inhibiting the proliferation ability of NPCs in late stages of neurogenesis.
 
Overall design We generated D6-Cre Ash2l conditional knockout mice.Through RNA-seq and ChIPseq of dorsal cortex from Ash2l WT and cKO mice to identify the role of Ash2l during corticogenesis
 
Contributor(s) Peng X, Li L
Citation(s) 31315048
Submission date Oct 09, 2018
Last update date Oct 18, 2019
Contact name Xiaozhong Peng
E-mail(s) pengxiaozhong@pumc.edu.cn
Phone 86 69156434
Organization name Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College
Department Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences
Lab Lab of Xiaozhong Peng
Street address No.5, Dongdan Santiao, Dongcheng District
City Beijing
ZIP/Postal code 100005
Country China
 
Platforms (2)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (5)
GSM3423435 Ash2l_WT_Rep1_AM_ChIPSeq
GSM3423436 Ash2l_WT_Rep2_AM_ChIPSeq
GSM3423439 Input_AM_DNA
This SubSeries is part of SuperSeries:
GSE120988 COMPASS Family Histone Methyltransferase ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling
Relations
BioProject PRJNA495177
SRA SRP164690

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Supplementary file Size Download File type/resource
GSE120987_RAW.tar 690.5 Mb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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