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Series GSE118933 Query DataSets for GSE118933
Status Public on May 17, 2019
Title Immune Checkpoint Regulation of Pulmonary Fibrosis [bulk RNA-seq]
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Fibroblasts from idiopathic pulmonary fibrosis (IPF) patients acquire an invasive phenotype that is essential for progressive fibrosis. The immune checkpoint ligand CD274 (PD-L1) is up-regulated on invasive lung fibroblasts, regulated by P53 and FAK signaling, and drives lung fibrosis in a humanized IPF model in mice. Targeting CD274high fibroblasts blunted invasion in vitro and attenuated fibrosis in vivo, suggesting that CD274 may be a novel therapeutic target in IPF.
Overall design Reveal of the expression of the checkpoint PD1 ligand CD274 in invasive and non-invasive fibroblasts of both normal human lungs and IPF lungs
Contributor(s) Geng Y, Liu X, Liang J, Deng N, Wang Y, Jiang D, Noble PW
Citation(s) 30763282, 35980387
Submission date Aug 22, 2018
Last update date Oct 26, 2022
Contact name AGCT Core
Organization name Cedars Sinai Medical Center
Department BMS
Street address 8687 Melrose Ave, PDC B230
City West Hollywood
State/province CA
ZIP/Postal code 90069
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (18)
GSM3351360 IPF_invasive_1
GSM3351361 IPF_invasive_3
GSM3351362 IPF_invasive_4
BioProject PRJNA487358
SRA SRP158619

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Supplementary file Size Download File type/resource
GSE118933_IPF_invasive_non-invasive_RPKM.txt.gz 1.8 Mb (ftp)(http) TXT
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