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Series GSE117582 Query DataSets for GSE117582
Status Public on Feb 18, 2019
Title Anti-cancer drugs curaxins target the 3D genome organization [HiC]
Organism Homo sapiens
Experiment type Other
Summary We have recently discovered a class of anti-cancer agents, curaxins, which suppress transcription of oncogenes. Here we demonstrate that curaxins preferentially downregulate expression of genes controlled by enhancers and super-enhancers via interrupting enhancer/promoter spatial communication. Our observations made both on a model of enhancer-regulated transcription of chromatinized template and on cultured cancer cells allow classifying curaxins as a novel type of epigenetic drugs that target the 3D genome organization.
Overall design Processed and raw HiC data for control and CBL0137-treated HT1080 cells.
Contributor(s) Luzhin A, Razin S
Citation(s) 30926878
Submission date Jul 24, 2018
Last update date Apr 09, 2019
Contact name Artem Luzhin
Organization name Institute of Gene Biology RAS
Street address Vavilova 34/5
City Moscow
ZIP/Postal code 119334
Country Russia
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (4)
GSM3304262 HiC_library_Control_replicate1
GSM3304263 HIC_library_CBL0137-treated_replicate1
GSM3304264 HIC_library_Conrtol_replicate2
This SubSeries is part of SuperSeries:
GSE122463 Anti-cancer drugs curaxins target the 3D genome organization
BioProject PRJNA482566
SRA SRP154986

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Supplementary file Size Download File type/resource
GSE117582_RAW.tar 358.1 Mb (http)(custom) TAR (of COOL)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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