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Series GSE117571 Query DataSets for GSE117571
Status Public on Jul 25, 2018
Title Foxc1 and Foxc2 are necessary to maintain glomerular podocytes
Organism Mus musculus
Experiment type Expression profiling by array
Summary Foxc1 and Foxc2 are highly expressed in adult podocytes. To bypass embryonic lethality of Foxc1 and Foxc2 KO, mice ubiquitously expressing inducible-Cre (ROSA26-CreERT2) were mated with floxed-Foxc1 and floxed-Foxc2 mice.
We used microarrays to detail effects of deletions of Foxc1 and Foxc2 on podocyte gene expression profiles in adult podocyte in vivo and in vitro.
Overall design The CreERT2 was activated in adult mice by administrations of tamoxifen. Isolated glomeruli were subjected to total RNA preparation. Altanatively, primaly cultured podocytes were treated with the active form of tamoxifen and total RNA was prepared on 4 or 7 days after the treatment.
Contributor(s) Motojima M
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Submission date Jul 24, 2018
Last update date Aug 05, 2018
Contact name Masaru Motojima
Organization name Tokai University School of Medicine
Department Clinical Pharmacology
Street address 143 Shimokasuya
City Isehara
State/province Kanagawa
ZIP/Postal code 259-1193
Country Japan
Platforms (1)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (12)
GSM3304015 Glomeruli of control mouse No.1
GSM3304016 Glomeruli of control mouce No.2
GSM3304017 Glomeruli of tamoxufen-treated mouse No.1
BioProject PRJNA482531

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE117571_RAW.tar 25.6 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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