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Series GSE116542 Query DataSets for GSE116542
Status Public on Jul 03, 2018
Title Expression data of exosomal miRNAs extracted from plasma [Affymetrix miRNA 4.0]
Platform organism synthetic construct
Sample organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Tuberculosis (TB) is difficult to diagnose under complex clinical conditions. Exosomal miRNAs have emerged as promising disease biomarkers. We aim to investigate the potential of exosomal miRNAs to assist with TB clinical diagnosis.
In the present research, we used the Affymetrix Genechip miRNA 4.0 Array to investgate the profiles of differentially expressed miRNAs (DEMs) in the exosomes of peripheral blood plasma. As a result, exosomal miRNA profiling yielded a total of 102 DEMs (98 with up-expression and 4 with down-expression) between the TB (pulmonary tuberculosis and tuberculosis meningitis) patients and controls.
 
Overall design Peripheral blood samples of 11 TB patients and 8 healthy individuals were collected for the for exosomal miRNAs extraction and hybridization on Affymetrix microarrays. In TB group, the most frequent (PTB) and the most lethal (TBM) forms were selected: PTB-1, PTB-2, PTB-3, PTB-4, PTB-5, PTB-6, PTB-7, TBM-1, TBM-2, TBM-3 and TBM-4. Meanwhile, 8 healthy individuals were selected as controls: HC-1, HC-2, HC-3, HC-4, HC-5, HC-6, HC-7 and HC-8.
 
Contributor(s) Hu X, Liao S, Bai H, Wu L, Wang M, Wu Q, Zhou J, Jiao L, Chen X, Zhou Y, Lu X, Ying B, Zhang Z, Li W
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Submission date Jul 02, 2018
Last update date Aug 29, 2018
Contact name Bai Hao
E-mail(s) 1126094210@qq.com
Phone +8618702898559
Organization name West China Hospital of Sichuan University
Department Laboratory Medicine
Street address Wuhou District Guoxue Lane 37
City Chengdu
State/province Sichuan
ZIP/Postal code 610041
Country China
 
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (19)
GSM3242482 PTB patient-1
GSM3242483 PTB patient-2
GSM3242484 PTB patient-3
Relations
BioProject PRJNA478956

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116542_RAW.tar 12.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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