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Series GSE116347 Query DataSets for GSE116347
Status Public on Dec 21, 2018
Title Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types.
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We reported transcriptional characterization of tumor-infiltrating T regulatory cells (TITRs) that is shared between species and among different tumor types and stages. We genomically profiled immunocytes from 2 species: 1. Mouse: CD4+ Treg and Tconv, and CD8+ T cells from tumor and spleen of B16, MC38 or CT26 tumor bearing mice, as well as from spleens of non-tumor bearing mice. 2. Human: CD4+ Treg cells from surgically resected and cryopreserved human colorectal carcinomas or normal colon tissue.
 
Overall design Gene expression profiles of CD4+ Treg and Tconv, and CD8+ T cells from tumor and spleen of B16, MC38 or CT26 tumor bearing mice (biological triplicates), as well as from spleens of non-tumor bearing mice, and CD4+ Treg cells from 12 surgically resected and cryopreserved human colorectal carcinomas or normal colon tissue.
 
Contributor(s) Magnuson A, Benoist C, Mathis D
Citation(s) 30348759
Submission date Jun 27, 2018
Last update date Mar 26, 2019
Contact name CBDM Lab
E-mail(s) cbdm@hms.harvard.edu
Phone 617-432-7747
Organization name Harvard Medical School
Department Microbiology and Immunobiology
Lab CBDM
Street address 77 Avenue Louis Pasteur
City Boston
State/province MA
ZIP/Postal code 02215
Country USA
 
Platforms (2)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (78)
GSM3229551 NoTumor.Sp.CD8#1
GSM3229552 NoTumor.Sp.CD8#2
GSM3229553 NoTumor.Sp.Tc#1
Relations
BioProject PRJNA478226
SRA SRP151471

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116347_Gene_count_table_human.csv.gz 738.3 Kb (ftp)(http) CSV
GSE116347_Gene_count_table_mouse.csv.gz 1.7 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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