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Series GSE116185 Query DataSets for GSE116185
Status Public on Sep 13, 2018
Title A NAFLD Model Created By Endoplasmic Reticulum Stress Response-Associated Steatosis in Human Induced Pluripotent Stem Cell-Derived Hepatocytes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our study reports a phenotypic approach to model hepatic steatosis in induced pluripotent stem cell-derived hepatocytes
Overall design hiPSCs, differentiated into functional hepatocytes that exhibited classic hepatocyte-associated bio-functions, were subjected to lipid overload and challenged with acute induced-ER stress developed a steatotic phenotype used to model hepatic steatosis in vitro. The quantification of lipid induction was performed by fluorescent high-content imaging.
Contributor(s) Parafati M, Siobhan M
Citation(s) 30254132, 33334026
Submission date Jun 22, 2018
Last update date Jan 04, 2021
Contact name Maddalena Parafati
Organization name SBPMRI
Department Conrad Prebys Center for Chemical Genomics
Street address 6400 Sanger rd
City Orlando
State/province FL
ZIP/Postal code 32827
Country USA
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (4)
GSM3212769 iPSC-Hep_RNAseq 1
GSM3212770 iPSC-Hep_RNAseq 2
GSM3212771 iPSC-Hep_RNAseq 3
BioProject PRJNA477582
SRA SRP151159

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116185_RAW.tar 1.1 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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