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Series GSE116185 Query DataSets for GSE116185
Status Public on Sep 13, 2018
Title A NAFLD Model Created By Endoplasmic Reticulum Stress Response-Associated Steatosis in Human Induced Pluripotent Stem Cell-Derived Hepatocytes
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Our study reports a phenotypic approach to model hepatic steatosis in induced pluripotent stem cell-derived hepatocytes
 
Overall design hiPSCs, differentiated into functional hepatocytes that exhibited classic hepatocyte-associated bio-functions, were subjected to lipid overload and challenged with acute induced-ER stress developed a steatotic phenotype used to model hepatic steatosis in vitro. The quantification of lipid induction was performed by fluorescent high-content imaging.
 
Contributor(s) Parafati M, Siobhan M
Citation(s) 30254132, 33334026
Submission date Jun 22, 2018
Last update date Jan 04, 2021
Contact name Maddalena Parafati
E-mail(s) parafatimaddalena@gmail.com
Organization name SBPMRI
Department Conrad Prebys Center for Chemical Genomics
Lab HTS
Street address 6400 Sanger rd
City Orlando
State/province FL
ZIP/Postal code 32827
Country USA
 
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (4)
GSM3212769 iPSC-Hep_RNAseq 1
GSM3212770 iPSC-Hep_RNAseq 2
GSM3212771 iPSC-Hep_RNAseq 3
Relations
BioProject PRJNA477582
SRA SRP151159

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE116185_RAW.tar 1.1 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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