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Series GSE115973 Query DataSets for GSE115973
Status Public on Jan 14, 2020
Title Impact of HSF1 and HSF2 on gene expression in normal growth conditions and upon proteotoxic stress.
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary RNA sequencing (RNA-seq) was used to study the impact of heat shock factors 1 and 2 (HSF1 and HSF2) on gene expression in normal growth conditions, upon Bortezomib-induced proteasome inhibition (25 nM, 6 h or 10 h), and upon heat shock (42∘C, 1 h).
Overall design U2OS WT, HSF1 KO, and HSF2 KO were treated with 25 nM of Bortezomib for 6 h or 10 h, or heat shocked at 42 degrees for 1 h. Samples were prepared in biological quadruplets.
Contributor(s) Joutsen J, Da Silva AJ, Luoto JC, Budzynski MA, Nylund AS, de Thonel A, Concordet J, Mezger V, Sabéran-Djoneidi D, Henriksson E, Sistonen L
Citation(s) 31940498
Submission date Jun 18, 2018
Last update date Apr 23, 2020
Contact name Jenny Maaria Joutsen
Organization name Åbo Akademi University
Department Cell Biology
Lab Lea Sistonen
Street address Tykistökatu 6A
City Turku
State/province Varsinais-Suomi
ZIP/Postal code 20520
Country Finland
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (48)
GSM3197021 C_WT_rep1
GSM3197022 6h_WT_rep1
GSM3197023 10h_WT_rep1
BioProject PRJNA476608
SRA SRP150792

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115973_NormalizedData_withAnnotations.xls.gz 8.5 Mb (ftp)(http) XLS
GSE115973_RAW.tar 322.9 Mb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data are available on Series record

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