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| Status |
Public on Apr 08, 2019 |
| Title |
Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease] |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that well-defined xenograft models of leading sources of CNS metastasis (melanoma, breast cancer, lung cancer) undergo specific transcriptomic alterations upon entering the brain microenvironment. This dataset can be utilized to explore the mechanisms of tumor cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.
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| Overall design |
Examination of the transcriptomic profiles of lung cancer, breast cancer, and melanoma models of brain metastatic disease and the resulting gene expression changes of the stroma in the tumor-bearing brain.
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| Contributor(s) |
Wingrove E, Liu ZZ, Nguyen DX |
| Citation missing |
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| Submission date |
Jun 12, 2018 |
| Last update date |
Apr 09, 2019 |
| Contact name |
Don Nguyen |
| E-mail(s) |
don.nguyen@yale.edu
|
| Phone |
2037374514
|
| Organization name |
Yale Shcool of Medicine
|
| Street address |
310 Cedar St
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520 |
| Country |
USA |
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| Platforms (3) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL22245 |
Illumina HiSeq 2500 (Homo sapiens; Mus musculus) |
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| Samples (22)
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| This SubSeries is part of SuperSeries: |
| GSE115702 |
Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis |
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| Relations |
| BioProject |
PRJNA475788 |
| SRA |
SRP150367 |
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