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Series GSE115701 Query DataSets for GSE115701
Status Public on Apr 08, 2019
Title Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [MultiDisease]
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We report that well-defined xenograft models of leading sources of CNS metastasis (melanoma, breast cancer, lung cancer) undergo specific transcriptomic alterations upon entering the brain microenvironment. This dataset can be utilized to explore the mechanisms of tumor cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.
Overall design Examination of the transcriptomic profiles of lung cancer, breast cancer, and melanoma models of brain metastatic disease and the resulting gene expression changes of the stroma in the tumor-bearing brain.
Contributor(s) Wingrove E, Liu ZZ, Nguyen DX
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Submission date Jun 12, 2018
Last update date Apr 09, 2019
Contact name Don Nguyen
Phone 2037374514
Organization name Yale Shcool of Medicine
Street address 310 Cedar St
City New Haven
State/province CT
ZIP/Postal code 06520
Country USA
Platforms (3)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL17021 Illumina HiSeq 2500 (Mus musculus)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (22)
GSM3187914 A.2D Rep 1
GSM3187915 A.2D Rep 2
GSM3187916 A.2D Rep 3
This SubSeries is part of SuperSeries:
GSE115702 Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis
BioProject PRJNA475788
SRA SRP150367

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115701_hg38.rpkm.csv.gz 2.5 Mb (ftp)(http) CSV
GSE115701_mm10.rpkm.csv.gz 2.4 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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