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Series GSE115700 Query DataSets for GSE115700
Status Public on Apr 08, 2019
Title Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_SQ_2D]
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary We find that malignant LUAD tumor cells grown in the brain microenvironment display significantly altered transcriptomic profiles when compared to tumor cells grown in monolayer or subcutaneously. Additionally, we characterize the reciprocal neuroinflammatory response of the surrounding brain stroma to metastatic LUAD. This dataset can be utilized to explore the mechanisms of LUAD cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.
Overall design Examination of the transcriptomic profiles of LUAD cells grown in different microenvironments (i.e., Brain, subcutaneous, monolayer culture) and the corresponding gene expression alterations of the stroma in the tumor-bearing brain.
Contributor(s) Wingrove E, Liu ZZ, Nguyen DX
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Submission date Jun 12, 2018
Last update date Apr 09, 2019
Contact name Don Nguyen
Phone 2037374514
Organization name Yale Shcool of Medicine
Street address 310 Cedar St
City New Haven
State/province CT
ZIP/Postal code 06520
Country USA
Platforms (2)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL22245 Illumina HiSeq 2500 (Homo sapiens; Mus musculus)
Samples (21)
GSM3187893 2D Rep 1
GSM3187894 2D Rep 2
GSM3187895 2D Rep 3
This SubSeries is part of SuperSeries:
GSE115702 Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis
BioProject PRJNA475787
SRA SRP150366

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Supplementary file Size Download File type/resource
GSE115700_hg38.rpkm.csv.gz 2.3 Mb (ftp)(http) CSV
GSE115700_mm10.rpkm.csv.gz 3.0 Mb (ftp)(http) CSV
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Raw data are available in SRA
Processed data are available on Series record

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