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| Status |
Public on Apr 08, 2019 |
| Title |
Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis [BrainMet_SQ_2D] |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We find that malignant LUAD tumor cells grown in the brain microenvironment display significantly altered transcriptomic profiles when compared to tumor cells grown in monolayer or subcutaneously. Additionally, we characterize the reciprocal neuroinflammatory response of the surrounding brain stroma to metastatic LUAD. This dataset can be utilized to explore the mechanisms of LUAD cell plasticity as well as the co-adaptation of the brain microenvironment to metastatic disease.
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| Overall design |
Examination of the transcriptomic profiles of LUAD cells grown in different microenvironments (i.e., Brain, subcutaneous, monolayer culture) and the corresponding gene expression alterations of the stroma in the tumor-bearing brain.
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| Contributor(s) |
Wingrove E, Liu ZZ, Nguyen DX |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 12, 2018 |
| Last update date |
Apr 09, 2019 |
| Contact name |
Don Nguyen |
| E-mail(s) |
don.nguyen@yale.edu
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| Phone |
2037374514
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| Organization name |
Yale Shcool of Medicine
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| Street address |
310 Cedar St
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| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06520 |
| Country |
USA |
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| Platforms (2) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
| GPL22245 |
Illumina HiSeq 2500 (Homo sapiens; Mus musculus) |
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| Samples (21)
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| This SubSeries is part of SuperSeries: |
| GSE115702 |
Transcriptomic hallmarks of tumor plasticity and stromal interactions in brain metastasis |
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| Relations |
| BioProject |
PRJNA475787 |
| SRA |
SRP150366 |
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