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Series GSE115501 Query DataSets for GSE115501
Status Public on Jan 24, 2020
Title RNA sequencing on circulating tumor cells from prostate cancer patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Circulating tumor cells (CTCs) undergo considerable stress in the bloodstream. To understand the underlying phenomenon, we conducted single-cell genomic or transcriptomic analyses of primary tumor cells shed in urine and CTCs in blood of prostate cancer patients. Of more than four hundred focal genomic alterations analyzed, increased and decreased copy-numbers of 113 recurrent regions were found in CTCs relative to primary tumor cells. Tumor cells with these pre-existing genomic alterations can be adaptively selected, allowing for transcription reprogramming during blood circulation. These regions harbored genes associated with oxidative phosphorylation machineries that are exploited by CTCs for alternative energy metabolism.
Overall design Examination of prostate CTCs transcriptomic profile in single cell level
Contributor(s) Liss MA
Citation(s) 31805710
Submission date Jun 08, 2018
Last update date Jan 24, 2020
Contact name Chun-Lin Lin
Phone 2104508471
Organization name University of Texas Health Science Center at San Antonio
Street address 7703 Floyd Curl Dr., MC8257, 233 STRF
City San Antonio
State/province Texas
ZIP/Postal code 78229
Country USA
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (136)
GSM3179512 VTC004_2_02_S196
GSM3179513 VTC004_2_06_S51
GSM3179514 VTC004_2_07_S198
BioProject PRJNA475218
SRA SRP150061

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE115501_RAW.tar 279.3 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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