GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE114932 Query DataSets for GSE114932
Status Public on Apr 10, 2020
Title Translin KO mice display elevated adiposity
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary The high prevalence of obesity has focused attention on defining the pathophysiological processes that underlie susceptibility or resistance to its deleterious metabolic consequences. Mice lacking translin (Tsn), a gene implicated in a variety of biological functions from transcription to microRNA degradation, display extremely high levels of adiposity, comparable to those found in well-known genetic models of obesity, such as melanocortin 4 receptor or leptin knockout (KO) mice. Although translin KO mice display increased adiposity they retain normal glucose tolerance.
In contrast, wild-type (WT) mice placed on a high-fat diet until they match translin KO adiposity levels are glucose intolerant, as expected. Conversely, translin KO mice display prominent hepatic steatosis that is more severe than that of adiposity-matched WT mice. The ability of translin KO mice to retain normal glucose tolerance in the face of massive tissue expansion may be due to three factors: preferential accumulation of subcutaneous fat, reduced levels of TNF mRNA in both adipose and hepatic tissue, and elevated levels of plasma adiponectin. Further studies aimed at defining the molecular bases for these phenotypes may yield new approaches to limit the adverse metabolic consequences of obesity.
Overall design Comparison between adipose tissue microRNA expression levels from adult, male translin KO mice and wildtype (WT) mice with six biological replicates per group.
Contributor(s) Baraban JM, Shah A, Fu X, Talbot CC Jr
Citation(s) 30647452
Submission date May 25, 2018
Last update date Apr 10, 2020
Contact name Jay M Baraban
Organization name The Johns Hopkins University School of Medicine
Department Neuroscience
Lab WBSB 908
Street address 725 North Wolfe Street
City Baltimore
State/province MD
ZIP/Postal code 21205
Country USA
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (12)
GSM3155154 1474: WT_1
GSM3155155 1493: WT_2
GSM3155156 1509: WT_3
BioProject PRJNA473148

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE114932_RAW.tar 8.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap