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Series GSE114362 Query DataSets for GSE114362
Status Public on Mar 19, 2019
Title Autocrine Motility Factor Modulates Proliferation Signaling Mediated By GPER
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Traditional surgery plus radiotherapy or chemotherapy, existing targeted therapies failed to significantly improve the survival rate of recurrent endometrial cancer, so suggesting that mechanism of recurrence and progression that modulates in endometrial cancer is clinically important. Here, we show that GPER(G protein-coupled estrogen receptor 1) was binded to AMF, and the complex were translocation form plasma to cytoplasmic. Mechanistic investigations elucidated that interaction of AMF with GPER triggers phosphoinositide-3-kinase (PI3K) signaling activating and accelerating the ability of endometrial cancer cells growth. Furthermore, we found that AMF may contribute to GPER-mediated endometrial cancer progression using animal experiments and human histological experiments which be consistent with the above conclusions. On the basis of these evidences including invivo and invitro, our findings suggest that AMF–GPER interaction might be novel key molecular targets for therapeutic management of patients with endometrial cancer, whose disease were progression and recurrence.
Overall design endometrial cancer was used in this experiment and data analysis of the 4 samples have been completed.spec-2/shAMFR VS spec-2, Ishikawa/shAMFR VS Ishikawa
Contributor(s) li y, wan x
Citation(s) 30836961
Submission date May 11, 2018
Last update date Mar 19, 2019
Contact name yiran li
Phone 15216688183
Organization name Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
Street address Gaoke West Road 2699
City shanghai
ZIP/Postal code 201204
Country China
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (4)
GSM3140465 spec-2/shAMFR
GSM3140466 spec-2
GSM3140467 ISK/shAMFR
BioProject PRJNA471076

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE114362_RAW.tar 49.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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