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Series GSE113864 Query DataSets for GSE113864
Status Public on May 01, 2018
Title Impact of Lmo2 expression on cell lineage decision during T-cell leukemogenesis [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary The goal of this study is compare the transcriptome profilling of different genetically engineered mouse models to the Human scenerio, in order to better understand the role of Lmo2 expression on cell lineage decision during T-cell leukemogenesis.
Results: The up-regulated Rosa26-Lmo2+Sca1-Cre and Sca1-Lmo2 signatures shows a significant enrichment in the human T-ALL group.
Conclusion: The similarity between Rosa26-Lmo2+Sca1-Cre and Human T-ALL signature is in accordance to the Human T-ALL situation wherein the expression of LMO2 is present throughout in tumor cells.
Overall design 14 samples were analyzed representing different mouse model employed in the study, including 4 control samples obtained from healthy thymus.
Contributor(s) García-Ramírez I, Bhatia S, Rodríguez-Hernández G, González-Herrero I, Walter C, González de Tena-Dávila S, Parvin S, Haas O, Woessmann W, Stanulla M, Schrappe M, Dugas M, Natkunam Y, Orfao A, Domínguez V, Pintado B, Blanco O, Alonso-López D, De Las Rivas J, Martín-Lorenzo A, Jiménez R, García Criado FJ, García Cenador MB, Lossos IS, Vicente-Dueñas C, Borkhardt A, Hauer J, Sánchez-García I
Citation(s) 29880602
Submission date Apr 30, 2018
Last update date May 18, 2019
Contact name Isidro Sánchez García
Organization name Inst. de Inv. Biomédica de Salamanca (IBSAL). H. U. de Salamanca. Inst. de Biología Molecular y Celular del Cáncer (IBMCC).
Department Centro de inv. del Cáncer (CIC).
Street address Campus Miguel de Unamuno
City Salamanca
ZIP/Postal code E37007
Country Spain
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (14)
GSM3121901 Aid.Cre
GSM3121902 Mb1.Cre.1
GSM3121903 Mb1.Cre.2
This SubSeries is part of SuperSeries:
GSE83572 LMO2 expression in HSCs causes T-ALL in the presence of an intact thymic niche
BioProject PRJNA454297
SRA SRP144047

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113864_rawCounts.xls.gz 2.5 Mb (ftp)(http) XLS
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Raw data are available in SRA
Processed data are available on Series record

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