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Series GSE113667 Query DataSets for GSE113667
Status Public on Jun 01, 2020
Title Influence of G. lamblia infection on the transcriptional profile in intestinal and liver tissue [intestinal epithelial cells]
Organism Mus musculus
Experiment type Expression profiling by array
Summary G. lamblia is a fecal-oral transmitted human enteropathogenic protozoan with extremely high incidence in endemic areas in Africa and Asia particularly in the infant population. It homes to the proximal small intestine and induced diarrhea and malabsoption. Here we established a novel murine G. lamblia infection model and analyzed the tissue response and downstream microbial and metabolic effects in the host.
Overall design Neonate mice at the age of 3-4 days were orally infected by gavage with 2x105 G. lamblia ATCC 5058 (assemblage B, strain GS, clone H7) trophozoites. The infection was monitored by antigen ELISA and quantitative PCR using weekly fecal samples as well as histology, transcriptional analysis of total gut tissue, isolated intestinal epithelial cells (Lotz et al., JEM, 2006) and total liver tissue as well as metabolic analysis in blood, intestinal content and liver tissue.
Contributor(s) Hornef MW, Riba AL, Hassani K
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Submission date Apr 25, 2018
Last update date Jun 23, 2023
Contact name Mathias W. Hornef
Phone +491702210495
Organization name RWTH √Āachen University
Department Medical Microbiology
Street address Steppenbergallee 203
City Aachen
ZIP/Postal code 52074
Country Germany
Platforms (1)
GPL19795 Agilent-048306 026655AsQuadruplicatesOn4x180K 048295 [Probe Name version]
Samples (8)
GSM3110879 N-10830-C1 (IEC) (12079)
GSM3110880 N-11604-I1 (IEC) (12086)
GSM3110883 N-10830-C2 (IEC) (12080)
This SubSeries is part of SuperSeries:
GSE113668 Influence of G. lamblia infection on the transcriptional profile in intestinal and liver tissue
BioProject PRJNA453563

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113667_RAW.tar 261.2 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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