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Series GSE113156 Query DataSets for GSE113156
Status Public on Jun 06, 2019
Title Transcriptome change after tocilizumab therapy in rheumatoid arthritis patients
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We compared whole CD4+ and CD8+ T cells from frozen PBMC samples that were collected before and after treatment initiation of each patient with rheumatoid arthritis. Lists consisting of 858 and 950 differentially expressed genes were created from CD4 and CD8, respectively, and these were used for enrichment analysis. As a result, we found that certain pathways were downregulated after TCZ treatment in both CD4+ and CD8+ T cells, including mechanistic target of rapamycin complex 1 (mTORC1) signaling, the IL-2 pathway, and IFN-related genes.
 
Overall design Examination between before and after tocilizumab treatment of CD4 and CD8 T cell in rheumatoid arthritis patients
 
Contributor(s) Takeshita M, Takeuchi T, Okuzono Y
Citation(s) 31167762, 34404865
Submission date Apr 16, 2018
Last update date Aug 24, 2021
Contact name Masaru Takeshita
Organization name Keio University
Department Division of Rheumatology
Lab research park 6S8
Street address 35 shinanomachi
City sinjuku-ku
State/province Tokyo
ZIP/Postal code 160-8582
Country Japan
 
Platforms (1)
GPL17303 Ion Torrent Proton (Homo sapiens)
Samples (22)
GSM3098174 CD8_w0__R084_K9656: CD8 before treatment 1
GSM3098175 CD8_w24__R084_K7821: CD8 after treatment 1
GSM3098176 CD8_w0__R087_K8710: CD8 before treatment 2
Relations
BioProject PRJNA450318
SRA SRP140437

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE113156_RAW.tar 1.8 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
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