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Series GSE112930 Query DataSets for GSE112930
Status Public on Mar 23, 2019
Title Persistent accumulation of unrepaired DNA damage in rat cortical neurons: nuclear organization and ChIP-seq analysis of damaged DNA
Organism Rattus norvegicus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We investigated the nuclear topography, organization and genome-wide gH2AX distribution of unrepaired DNA in rat cortical neurons 15 dyas upon X-Ray ionizing adiation (4Gy). Unrepaired DNA is confined in persistent DNA damage foci which would help preserving genome integrity. ChIp-seq analysis revealed a number of genomic regions enriched in gH2AX. Some of these regions are in close proximity to genes encoding essential proteins for neuronal function and human neurodegenerative disorders.
Overall design ChIP-seq analysis of genome-wide gH2AX distribution in persistent DNA damage foci of unrepaired DNA in both irradiated and non-irradiated cortical neurons
Contributor(s) Mata-Garrido J, Tapia O, Casafont I, Berciano MT, Cuadrado A, Lafarga M
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Submission date Apr 10, 2018
Last update date Mar 24, 2019
Contact name Miguel Angel Lafarga
Phone 34 942201929
Organization name Faculty of Medicine
Department Department of Anatomy and Cell Biology
Street address Avd,. Cardenal Herrera Oria sn
City Santander
ZIP/Postal code 39011
Country Spain
Platforms (1)
GPL14844 Illumina HiSeq 2000 (Rattus norvegicus)
Samples (4)
GSM3091531 Control gH2AX
GSM3091532 IR treated_1 gH2AX
GSM3091533 IR treated_2 gH2AX
BioProject PRJNA449523

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Supplementary file Size Download File type/resource
GSE112930_RAW.tar 876.6 Mb (http)(custom) TAR (of BW)
Raw data are available in SRA
Processed data provided as supplementary file

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