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| Status |
Public on Sep 24, 2018 |
| Title |
Effects of Hnf4a deletion in the nephron lineage during kidney development |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The goal of our study is to determine if Hnf4a is required for the formation of proximal tubules during kidney development.
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| Overall design |
Method: Hnf4a floxed allele was deleted in the nephron lineage using Six2GFPcre. Mouse embryonic kidneys at E18.5 were collected and subjected to RNA-seq analysis
Examination of 4 groups; two controls (Hnf4a c/+ ; Six2GFPcre) and two mutants (Hnf4a c/c ; Six2GFPcre)
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| |
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| Contributor(s) |
Marable S, Chung E, Park J |
| Citation(s) |
30046000 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 DK100315 |
Cell Fate Regulation of Nephron Progenitors |
CHILDREN'S HOSPITAL MEDICAL CENTER |
Joo-Seop Park |
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| |
| Submission date |
Apr 06, 2018 |
| Last update date |
Mar 21, 2019 |
| Contact name |
Joo-Seop Park |
| Organization name |
Cincinnati Children's Hospital Medical Center
|
| Street address |
3333 Burnet Avenue
|
| City |
Cincinnati |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA449100 |
| SRA |
SRP137895 |
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