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Status |
Public on Mar 01, 2019 |
Title |
Identification of HOXB13 target genes responsive to BET inhibitors |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by high throughput sequencing
|
Summary |
We identified BRD4 as an epigenetic regulator of the prostate lineage specific gene HOXB13 during progression of the disease from an androgen dependent to an androgen independent state.
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Overall design |
Integrative analysis- we compared genes whose expression was significantly impacted either (up or downregulated) as a result of HOXB13 knockdown and were also sensitive to BET inhibition
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Contributor(s) |
Mahajan K, Perera R |
Citation(s) |
30242092 |
|
Submission date |
Mar 24, 2018 |
Last update date |
Mar 01, 2019 |
Contact name |
Kiran Mahajan |
E-mail(s) |
kiranm@wustl.edu
|
Phone |
3142737728
|
Organization name |
Washington University
|
Department |
Surgery
|
Lab |
Kiran Mahajan Lab
|
Street address |
CB 8242 600 South Euclid Ave
|
City |
St. Louis |
State/province |
Missouri |
ZIP/Postal code |
63110 |
Country |
USA |
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Platforms (1) |
GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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Samples (9)
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Relations |
BioProject |
PRJNA445557 |
SRA |
SRP136392 |