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Series GSE112095 Query DataSets for GSE112095
Status Public on Aug 28, 2018
Title Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation [RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary It has been shown that functional deficiency of SmcHD1, a noncanonical member of SMC family proteins, results in derepression of X-inactivated genes in postimplantation female mouse embryos. In this study, we found that derepression of X-inactivated genes accompanied a local reduction in the enrichment of H3K27me3 in mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1.
 
Overall design Allele-specific RNA-seq analysis of mouse embryonic fibroblasts (MEFs) prepared from female fetuses deficient for SmcHD1. The MEFs were obtained from B6-JF1 F1 males crossed with B6 females carrying Xist-deltaA mutation.
 
Contributor(s) Sakakibara Y, Nagao K, Obuse C, Sado T
Citation(s) 30126901
Submission date Mar 20, 2018
Last update date Sep 12, 2018
Contact name Koji Nagao
E-mail(s) nagao@bio.sci.osaka-u.ac.jp
Organization name Osaka University
Department Graduate School of Science
Lab Obuse Lab.
Street address 1-1 Machikaneyama
City Toyonaka
State/province Osaka
ZIP/Postal code 560 0043
Country Japan
 
Platforms (1)
GPL18480 Illumina HiSeq 1500 (Mus musculus)
Samples (4)
GSM3057415 smchd1WT.rep1
GSM3057416 smchd1WT.rep2
GSM3057417 smchd1MD1.rep1
This SubSeries is part of SuperSeries:
GSE112097 Role of SmcHD1 in the establishment of the epigenetic states required for the maintenance of X chromosome inactivation
Relations
BioProject PRJNA439360
SRA SRP136200

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE112095_allelic_expression.txt.gz 530.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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