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Series GSE11188 Query DataSets for GSE11188
Status Public on Jun 15, 2009
Title Gene-expression profiles of non-tumor-reactive CD8+ T cells
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Non-tumor-reactive T cells are characterized by the inabilitzy to lyse autologous tumor cells, low to intermediate avidity TCRs and lack of NY-ESO-1 peptide tetramer binding. However most strikingly, non-tumor-reactive T cells are characterized by a molecular program associated with ‘division arrest anergy’ with elevated expression of the inhibitory molecule p27kip1. This is accompanied by elevated expression of inhibitory molecules and reduced levels of transcription factors involved in T cell activation. Frequency analysis of the inhibited T cell population using the established molecular fingerprint as a novel biomarker might be applied for cancer vaccine development and optimization.
Keywords: cell type comparison
 
Overall design Genome-wide transcriptional changes in human non-tumor-reactive CD8+ T cell clones from NY-ESO-1 expressin tumor patients after peptide vaccination using Affymetrix HGU133A arrays.
 
Contributor(s) Beyer M, Schultze JL
Citation(s) 19435912
Submission date Apr 16, 2008
Last update date Aug 10, 2018
Contact name Joachim Schultze
E-mail(s) j.schultze@uni-bonn.de
Organization name LIMES (Life and Medical Sciences Center Genomics and Immunoregulation)
Department Genomics and Immunoregulation
Street address Carl-Troll-Strasse 31
City Bonn
State/province NRW
ZIP/Postal code 53115
Country Germany
 
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (4)
GSM281824 non-tumor-reactive CD8+ T cell clone p10
GSM281826 non-tumor-reactive CD8+ T cell clone p19
GSM281827 tumor-reactive CD8+ T cell clone p26
Relations
BioProject PRJNA106893

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE11188_RAW.tar 12.7 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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