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Status |
Public on Jun 15, 2009 |
Title |
Gene-expression profiles of non-tumor-reactive CD8+ T cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Non-tumor-reactive T cells are characterized by the inabilitzy to lyse autologous tumor cells, low to intermediate avidity TCRs and lack of NY-ESO-1 peptide tetramer binding. However most strikingly, non-tumor-reactive T cells are characterized by a molecular program associated with ‘division arrest anergy’ with elevated expression of the inhibitory molecule p27kip1. This is accompanied by elevated expression of inhibitory molecules and reduced levels of transcription factors involved in T cell activation. Frequency analysis of the inhibited T cell population using the established molecular fingerprint as a novel biomarker might be applied for cancer vaccine development and optimization. Keywords: cell type comparison
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Overall design |
Genome-wide transcriptional changes in human non-tumor-reactive CD8+ T cell clones from NY-ESO-1 expressin tumor patients after peptide vaccination using Affymetrix HGU133A arrays.
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Contributor(s) |
Beyer M, Schultze JL |
Citation(s) |
19435912 |
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Submission date |
Apr 16, 2008 |
Last update date |
Aug 10, 2018 |
Contact name |
Joachim Schultze |
E-mail(s) |
j.schultze@uni-bonn.de
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Organization name |
LIMES (Life and Medical Sciences Center Genomics and Immunoregulation)
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Department |
Genomics and Immunoregulation
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Street address |
Carl-Troll-Strasse 31
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City |
Bonn |
State/province |
NRW |
ZIP/Postal code |
53115 |
Country |
Germany |
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Platforms (1) |
GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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Samples (4)
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GSM281824 |
non-tumor-reactive CD8+ T cell clone p10 |
GSM281826 |
non-tumor-reactive CD8+ T cell clone p19 |
GSM281827 |
tumor-reactive CD8+ T cell clone p26 |
GSM281828 |
tumor-reactive CD8+ T cell clone p40 |
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Relations |
BioProject |
PRJNA106893 |