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Series GSE111705 Query DataSets for GSE111705
Status Public on Mar 13, 2018
Title Functional and genomic characterization of a xenograft model system for the study of metastasis in triple-negative breast cancer
Organism Homo sapiens
Experiment type Genome variation profiling by SNP array
Summary To define the molecular regulators of metastasis of triple-negative breast cancer, we conducted a rigorous characterization of four populations of MDA-MB-231 human triple-negative breast cancer cells that display a range of intrinsic spontaneous metastatic capacities in immuno-deficient mice, from non-metastatic to highly metastatic to lung, liver, spleen and spine. PAT-Seq gene expression profiling of primary tumor cells identified the fibroblast growth factor homologous factor, FGF13, as a candidate metastatic virulence gene highly upregulated in aggressively metastatic MDA-MB-231HM tumors.
Overall design SNP analysis from of 4 increasingly metastatic breast cancer tumour cell lines
Contributor(s) Johnstone CN, Pattison AD, Harrison PF, Powell DR, Lock P, Anderson RL, Beilharz TH
Citation(s) 29720474
Submission date Mar 12, 2018
Last update date May 09, 2018
Contact name Andrew Pattison
Organization name Monash University
Street address Wellington Rd
City Melbourne
State/province Vic
ZIP/Postal code 3800
Country Australia
Platforms (1)
GPL13829 Illumina HumanCytoSNP-12 v2.1 BeadChip
Samples (4)
GSM3037802 MDA-MB-231_ATCC_1
GSM3037803 MDA-MB-231_LNA_1
GSM3037804 MDA-MB-231_LM2_1
This SubSeries is part of SuperSeries:
GSE111706 Metastasis in triple-negative breast cancer
BioProject PRJNA437934

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE111705_RAW.tar 15.9 Mb (http)(custom) TAR (of IDAT)
GSE111705_signal_intensities.txt.gz 16.3 Mb (ftp)(http) TXT
Processed data included within Sample table

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