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Series GSE111233 Query DataSets for GSE111233
Status Public on Sep 20, 2018
Title Wound healing mechanisms in pathogenesis control in natural SIV host species [monocytes]
Organisms Chlorocebus aethiops; Macaca mulatta
Experiment type Expression profiling by high throughput sequencing
Summary We devised a systems biology approach to investigate the early host response to high-dose rectal SIV transmission, by transcriptomic comparative analysis of a natural reservoir host SIV model species, African green monkeys (AGMs – Chlorocebus sabaeus, N=28) and a pathogenic model, rhesus macaques (RMs - Macaca mulatta, N=24).on rectal tissues for both AGMs and RMs.
 
Overall design To investigate if AGM macrophages have a stronger wound healing profile compared to RM, we carried out mRNA sequencing on sorted M1 and M2 monocytes. Specifically, longitudinal blood samples were taken at D7, D14 and D28 post inoculation from two AGMs and four RMs
 
Contributor(s) Barrenas F, Raehetz K, Kristoff J, Green RR, Law L, Bosinger S, Silvestri G, Pandrea I, Gale M
Citation(s) 31704931
Submission date Feb 28, 2018
Last update date Nov 19, 2019
Contact name Michael Gale, Jr
E-mail(s) uw_galelab_geo@uw.edu
Organization name University of Washington
Department Immunology
Street address 750 Republican St. E360, Box 358059
City Seattle
State/province Washington
ZIP/Postal code 98109
Country USA
 
Platforms (2)
GPL21120 Illumina NextSeq 500 (Macaca mulatta)
GPL22096 Illumina NextSeq 500 (Chlorocebus aethiops)
Samples (45)
GSM3026843 R24Sil_RCt14_RM_SIV_SC_D14_1_Mono_RLT_mRNA_Seq_S3
GSM3026844 R24Sil_RCt14_RM_SIV_SC_D14_1_NCMono_RLT_mRNA_Seq_S7
GSM3026845 R24Sil_RCt14_RM_SIV_SC_D28_1_Mono_RLT_mRNA_Seq_S4
This SubSeries is part of SuperSeries:
GSE111234 Wound healing mechanisms in pathogenesis control in natural SIV host species
Relations
BioProject PRJNA436258
SRA SRP133647

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE111233_AGM_count_matrix_agm.txt.gz 356.2 Kb (ftp)(http) TXT
GSE111233_RM_count_matrix_rhesus.txt.gz 818.1 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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