|
| Status |
Public on Jun 04, 2020 |
| Title |
Mycobacterium tuberculosis cording in lymphatic endothelial cells (hLEC) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Mycobacterium tuberculosis (Mtb) displayed cording phenotypes during intracellular infection. RNA-Seq was used to identify transcriptional programmes expressed by hLEC that actviates pathways relating to cellular pro-survival and cyosolic surveillance of intracellular Mtb. Mtb cording was found to be a mechanism to evade xenophagy in the cytosol of endothelial cells.
|
| |
|
| Overall design |
A total of 6 samples were sequenced: 3 samples of Mtb-infected hLEC and 3 samples of uninfected hLEC
|
| |
|
| Contributor(s) |
Lai R, Gutierrez M, Lerner T |
| Citation(s) |
32369443 |
| |
| Submission date |
Feb 13, 2018 |
| Last update date |
Mar 29, 2023 |
| Contact name |
Rachel Lai |
| E-mail(s) |
rachel.lai@imperial.ac.uk
|
| Organization name |
Imperial College London
|
| Department |
Infectious Disease
|
| Street address |
Du Cane Road
|
| City |
London |
| ZIP/Postal code |
W12 0NN |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA433987 |
| SRA |
SRP132805 |
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