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Series GSE110468 Query DataSets for GSE110468
Status Public on Nov 22, 2019
Title Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells. [Epigenetics]
Organism Homo sapiens
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Human fetal naïve T cells preferentially differentiate into CD25hiFOXP3hi regulatory T (Treg) cells upon T cell receptor (TCR) stimulation, which contribute to the generation of immunotolerance in the developing human fetus. We utilized ATACseq and H3K27ac ChIPseq to characterize the human fetal naive T cell epigenome relative to that of adult naive T cells and Treg cells. Fetal naive T cells share a partial Treg epigenome with increased chromatin accessibility and H3K27ac enrichment at a subset of Treg-specific enhancers.
Overall design ATACseq and H3K27ac ChIPseq for ex vivo sorted adult CD4+CD25-CD45RA+CD27+ naïve T, adult CD4+CD25hiCD127lo regulatory T and fetal naïve T cells from fetal spleen and adult peripheral blood mononuclear cells
Contributor(s) Ng MS, Burt TD
Citation(s) 31757834
Submission date Feb 12, 2018
Last update date Feb 21, 2020
Contact name Melissa Ng
Organization name University of California, San Francisco
Lab Burt Lab
Street address 35 Medical Centre Way, Regeneration Medicine Building 903B
City San Francisco
State/province California
ZIP/Postal code 94143
Country USA
Platforms (2)
GPL16791 Illumina HiSeq 2500 (Homo sapiens)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (30)
GSM2991621 ATAC_ANrep1
GSM2991622 ATAC_ANrep2
GSM2991623 ATAC_ANrep3
This SubSeries is part of SuperSeries:
GSE110472 Helios enhances the preferential differentiation of human fetal CD4+ naïve T cells into regulatory T cells.
BioProject PRJNA433824
SRA SRP132691

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Supplementary file Size Download File type/resource
GSE110468_RAW.tar 11.5 Gb (http)(custom) TAR (of BW)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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