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Series GSE110403 Query DataSets for GSE110403
Status Public on Aug 06, 2019
Title Metabolic reprogramming of macrophage polarization by creatine [ATAC-seq]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary We found that the creatine metabolic pathway was differentially regulated under M1 versus M2 polarizing conditions. In return, creatine could suppress M1 by blocking STAT1 tyrosine phosphorylation while promote M2 by sustaining chromatin accessibility of specific gene loci.
 
Overall design Analyze the changes of chromatin accessibility in macrophages lack of creatine during macrophage polarization
 
Contributor(s) Ji L, Zhang B
Citation(s) 31399282
Submission date Feb 09, 2018
Last update date Nov 05, 2019
Contact name Liangliang Ji
E-mail(s) jll14@mails.tsinghua.edu.cn
Organization name Institute for Immunology
Department School of Medicine
Lab Xiaoyu Hu
Street address Tsinghua University
City Beijing
ZIP/Postal code 100084
Country China
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (4)
GSM2990821 ATACseq_BMDM_WT_UT
GSM2990822 ATACseq_BMDM_WT_IL4
GSM2990823 ATACseq_BMDM_KO_UT
This SubSeries is part of SuperSeries:
GSE110456 Metabolic reprogramming of macrophage polarization by creatine
Relations
BioProject PRJNA433645
SRA SRP132566

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE110403_RAW.tar 850.6 Mb (http)(custom) TAR (of BED, WIG)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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