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Series GSE109813 Query DataSets for GSE109813
Status Public on Dec 31, 2019
Title SNP data of Familial adenomatous polyposis (FAP) organoids
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Summary FAP is an autosomal-dominant inherited disease caused by germline mutations in the APC gene 1. Two major FAP phenotypes, CFAP and AFAP, can be distinguished based on polyp numbers and age of onset. CFAP is characterized by the presence of hundreds to thousands of polyps. About half of these patients develop adenomas by age 15, and 95% develop adenomas by age 35. AFAP patients exhibit a milder phenotype than CFAP patients; AFAP is characterized by fewer polyps, later adenoma onset, and lower CRC risk.
We used microarrays to analyze chromosome abberation of organids established from FAP patients.
Overall design Organoids were collected for DNA extraction and hybridization on Affymetrix microarrays. Each sample represents an independent organoid established from a patient. HCT number represents patient
Contributor(s) Yao R
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Submission date Jan 29, 2018
Last update date Jan 01, 2020
Contact name Ryoji Yao
Organization name The JFCR-Cancer Institute
Street address 3-8-31 Ariake
City Koto-ku
State/province Tokyo
ZIP/Postal code 135-8550
Country Japan
Platforms (1)
GPL6801 [GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array
Samples (8)
GSM2970345 FAP organoid, HCT14-2_SNP
GSM2970346 FAP organoid, HCT14-9_SNP
GSM2970347 FAP organoid, HCT20-3_SNP
This SubSeries is part of SuperSeries:
GSE109814 Expression data and SNP data of Familial adenomatous polyposis (FAP) organoids
BioProject PRJNA432077

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109813_RAW.tar 336.5 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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