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Series GSE109807 Query DataSets for GSE109807
Status Public on Jan 20, 2021
Title Aberrant RNA expression and splicing in childhood ETV6/RUNX1 acute lymphoblastic leukemia
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary ETV6/RUNX1 E/R -positive acute lymphoblastic leukemia (ALL), as one of the most common childhood malignancies, its pathogenesis and mechanism remain to be elucidated comprehensively. Global gene expression profiling can provide insight into the underlying pathophysiology of disease processes. In this study we sought to gain further insight into the molecular mechanisms underlying E/R-positive ALL by examining transcriptional profiles of E/R-positive ALL patients. We investigated the Bone marrow transcriptional profiles of E/R-positive ALL patients. Bioinformatic and statistical methods, including differential expression analysis, lncRNA analysis, alternative splicing analysis and metabolic network analysis, were used to characterize the underlying molecular mechanisms for E/R-positive ALL.
Overall design Examination of gene expression levels, splicing levels in ALL patients.
Contributor(s) Zhu X, Sun B, Sun C, Zhang T, Chang L
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Submission date Jan 29, 2018
Last update date Jan 22, 2021
Contact name Bao-Fa Sun
Organization name Beijing Institute of Genomics (BIG) of Chinese Academy of Sciences (CAS)
Street address Da-Tun Road
City Beijing
ZIP/Postal code 100101
Country China
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (4)
GSM2970245 ALL-Patient1
GSM2970246 ALL-Patient2
GSM2970247 ALL-Patient3
BioProject PRJNA432067
SRA SRP131689

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109807_RAW.tar 900.0 Kb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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