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Series GSE109761 Query DataSets for GSE109761
Status Public on Feb 06, 2019
Title Neutrophils Escort Circulating Tumor Cells to Enable Cell Cycle Progression
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Circulating tumor cells (CTCs) are precursors of metastasis in several cancer types, and are occasionally found within the bloodstream in association with non-malignant cells such as white blood cells (WBCs). The identity and function of these CTC-associated WBCs, as well as the molecular features that define the interaction between WBCs and CTCs are unknown. Here, we achieve the isolation and interrogation of individual CTC-associated WBCs, alongside with corresponding cancer cells within each CTC-WBC-cluster, from multiple breast cancer patients and mouse models.
Overall design Single-cell RNA-Seq from CTCs and CTC-WBC-clusters obtained from multiple breast cancer patients and mouse models were used to identify CTC-associated WBCs cell types and differential expression between CTCs alone and CTC-associated to WBC.
Contributor(s) Szczerba B, Castro-Giner F, Vetter M, Gkountela S, Landin J, Krol I, Donato C, Scherrer R, Singer J, Beisel C, Kurzeder C, Weber WP, Rochlitz C, Heinzelmann-Schwarz V, Beerenwinkel N, Aceto N
Citation(s) 30728496, 32905777
Submission date Jan 29, 2018
Last update date Oct 02, 2020
Contact name Francesc Castro-Giner
Organization name ETH Zurich
Street address Otto-​Stern-Weg 7
City Zurich
ZIP/Postal code CH-8093
Country Switzerland
Platforms (3)
GPL18573 Illumina NextSeq 500 (Homo sapiens)
GPL19057 Illumina NextSeq 500 (Mus musculus)
GPL19415 Illumina NextSeq 500 (Homo sapiens; Mus musculus)
Samples (470)
GSM2966406 LM2_A81
GSM2966407 LM2_A83
GSM2966408 LM2_A85
BioProject PRJNA431985
SRA SRP131647

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109761_RAW.tar 62.9 Mb (http)(custom) TAR (of TXT)
GSE109761_processed_normalized_matrix_hs.txt.gz 25.8 Mb (ftp)(http) TXT
GSE109761_processed_normalized_matrix_mm.txt.gz 8.2 Mb (ftp)(http) TXT
GSE109761_sce_hs.rds.gz 42.4 Mb (ftp)(http) RDS
GSE109761_sce_mm.rds.gz 14.9 Mb (ftp)(http) RDS
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

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