GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE109566 Query DataSets for GSE109566
Status Public on Aug 06, 2019
Title Transcriptome analysis of differentiated normal mouse urothelial organoids reveals novel pathways activated during urothelial differentiation
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Transcriptomic analysis revealed significant changes between organoids growing in full medium growth conditions (proliferative NMU-o) and deprived medium (differentiated NMU-o). Around 4100 genes are differentially expressed between both conditions. Moreover, GSEA analysis in proliferation showed pathways related to cell cycle, DNA repair, RNA biology and protein synthesis; in differentiation, pathways related to cellular traffic, cell-cell adhesion and notch signalling are up-regulated.
Overall design We established normal mouse urothelial organoids (NMU-o) from 3 independent samples and further induced differentiation. For each individual sample we sequenced the corresponding proliferation and differentiation stages.
Contributor(s) Santos CP, Millán I, Carrillo-de Santa Pau E, Real FX
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jan 24, 2018
Last update date Aug 08, 2019
Contact name Enrique Carrillo de Santa Pau
Organization name Spanish National Cancer Research Centre (CNIO)
Department Cancer Cell Biology Programme
Lab Epithelial Carcinogenesis group
Street address C/ Melchor Fernández Almagro, 3
City Madrid
ZIP/Postal code 28029
Country Spain
Platforms (1)
GPL24247 Illumina NovaSeq 6000 (Mus musculus)
Samples (6)
GSM2946662 60DIFF
GSM2946663 97DIFF
GSM2946664 98DIFF
BioProject PRJNA431400
SRA SRP131374

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109566_RAW.tar 409.6 Mb (http)(custom) TAR (of BW)
GSE109566_genes.fpkm_table.txt.gz 431.7 Kb (ftp)(http) TXT
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file
Processed data are available on Series record

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap