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Series GSE109528 Query DataSets for GSE109528
Status Public on Jan 24, 2018
Title RNA-seq analysis of HuH-7, NCI-H1299 and HEK-293T cells
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary The diversity and complexity of the cancer transcriptome hold the potential to yield tumor-specific transcripts (TSTs) in cancer. We report a novel LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. LIN28B-TST initiates from a de novo alternative transcription initiation site. We found that LIN28B-TST was expressed in HuH-7 HCC cells and NCI-H1299 lung cancer cells, while wild-type LIN28B (LIN28B-WT) was expressed in HEK-293T human embryo kidney cells.
Overall design Celluar RNAs were generated by deep sequencing using Illumina Hiseq.
Contributor(s) Huang S, Guo W
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Submission date Jan 23, 2018
Last update date Dec 23, 2018
Contact name Shenglin Huang
Organization name Fudan University
Street address 270 Dongan
City Shanghai
ZIP/Postal code 200032
Country China
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (3)
GSM2945852 HEK-293T
GSM2945853 HuH-7
GSM2945854 NCI-H1299
BioProject PRJNA431305
SRA SRP131169

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109528_Cell_fpkm_exp.txt.gz 593.7 Kb (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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