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Series GSE109297 Query DataSets for GSE109297
Status Public on Sep 25, 2018
Title The Effect of TLR2 Activation on Transcriptome of IFN-induced Microglia
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary In murine glioma models, TLR2 is selectively upregulated in glioma-associated microglia. We found that TLR2 activation led to down-regulation of MHC-II in microglia. Therefore, we examined the effect of TLR2 activation on IFN-gamma-induced microglial transcriptome by in vitro culture of murine adult microglia. In the study, we confirmed that TLR2 activation led to Ciita shutdown and inhibition of MHC-II related genes, which also revealed the role of TLR2 in inducing APC disability and tumor immune escape. In addition, this work can be used to reveal the transcriptional characteristics of murine microglia during IFN-gamma and TLR2 activation.
Overall design Examination of transcriptional characteristics in murine adult microglia under TLR2 agonist and IFN-gamma treatments.
Web link
Contributor(s) Qian J, Chu Y
Citation(s) 30131377
Submission date Jan 17, 2018
Last update date Mar 01, 2019
Contact name Jiawen Qian
Organization name Fudan University
Department Immunology
Lab Chu Lab
Street address 130 Dong'anĀ Road
City Shanghai
ZIP/Postal code 200032
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (11)
GSM2936667 Control rep1
GSM2936668 Control rep2
GSM2936669 Control rep3
BioProject PRJNA430373
SRA SRP131072

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Supplementary file Size Download File type/resource
GSE109297_gene_expression.txt.gz 3.0 Mb (ftp)(http) TXT
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Processed data are available on Series record

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