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| Status |
Public on May 05, 2018 |
| Title |
Boosting ATM activity alleviates ageing and extends lifespan in a mouse model of progeria. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Protein deacetylase SIRT6 and protein kinase ATM both decline during aging, which are of importance in regualtion of glucose metabolism . To explore the mechnisms of SIRT6 and ATM in glycolysis, we analysed the gene expressions in murine embryonic fibroblast cells generated from wildtype, Sirt6-/-, or Atm-/- mice.
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| |
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| Overall design |
The mRNA profiles of MEF cells from wildtype, Sirt6-/-, or Atm-/- not were generated by deep sequencing using Illumina HiSeq x ten
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| |
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| Contributor(s) |
Qian M, Liu B |
| Citation(s) |
29717979 |
| |
| Submission date |
Jan 17, 2018 |
| Last update date |
Mar 01, 2019 |
| Contact name |
Min Xian Qian |
| E-mail(s) |
qmx@szu.edu.cn
|
| Organization name |
Shenzhen University
|
| Department |
Health Science Center
|
| Street address |
3688 Nanhai Ave
|
| City |
Shenzhen |
| ZIP/Postal code |
518060 |
| Country |
China |
| |
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| Platforms (1) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA430333 |
| SRA |
SRP131033 |
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