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Series GSE109280 Query DataSets for GSE109280
Status Public on May 05, 2018
Title Boosting ATM activity alleviates ageing and extends lifespan in a mouse model of progeria.
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Protein deacetylase SIRT6 and protein kinase ATM both decline during aging, which are of importance in regualtion of glucose metabolism . To explore the mechnisms of SIRT6 and ATM in glycolysis, we analysed the gene expressions in murine embryonic fibroblast cells generated from wildtype, Sirt6-/-, or Atm-/- mice.
Overall design The mRNA profiles of MEF cells from wildtype, Sirt6-/-, or Atm-/- not were generated by deep sequencing using Illumina HiSeq x ten
Contributor(s) Qian M, Liu B
Citation(s) 29717979
Submission date Jan 17, 2018
Last update date Mar 01, 2019
Contact name Min Xian Qian
Organization name Shenzhen University
Department Health Science Center
Street address 3688 Nanhai Ave
City Shenzhen
ZIP/Postal code 518060
Country China
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (9)
GSM2936416 WT -1
GSM2936417 WT -2
GSM2936418 WT -3
BioProject PRJNA430333
SRA SRP131033

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE109280_RAW.tar 3.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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