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Series GSE108090 Query DataSets for GSE108090
Status Public on Dec 11, 2018
Title Epigenetic control of genes and transposable elements [inhibitor RNA-seq]
Organism Mus musculus
Experiment type Expression profiling by high throughput sequencing
Summary Epigenetic control is an elaborate system the cell uses to control aspects of cell type and gene control. Histones and DNA are chemically modified to signal epigenetic information as to whether a gene is active or inactive, and so maintain cell type stability. Whilst epigenetic control of genes has been explored, the control of the rest of the genome is less well explored. The bulk of DNA and chromatin consists of repetitive elements, not genes, and these TEs must be tightly regulated to provide structure and function for nearby genes and, ultimately, cell type control. In this project we explore the intereaction of epigenetic control factors, and inhibitors, and how perturbation of the epigenetic control system disrupts TE regulation inside embryonic stem cells.
 
Overall design We analyzed the transcriptome expression profiles(RNA-seq) and chromation accessibility(ATAC-seq) upon specific epigenetic perturbation
 
Contributor(s) He J, Hutchins AP
Citation(s) 30604769
Submission date Dec 14, 2017
Last update date Mar 12, 2019
Contact name Jiangping He
E-mail(s) he_jiangping@grmh-gdl.cn
Organization name Guangzhou Institutes of Biomedicine and Health (GIBH), CAS
Street address Kai yuan avenue 190
City GuangZhou
ZIP/Postal code 510530
Country China
 
Platforms (1)
GPL21273 HiSeq X Ten (Mus musculus)
Samples (22)
GSM2889424 Bromosporine.rep1
GSM2889425 Bromosporine.rep2
GSM2889426 CPTH2.rep1
This SubSeries is part of SuperSeries:
GSE108091 Epigenetic control of genes and transposable elements
Relations
BioProject PRJNA422435
SRA SRP126768

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE108090_inhibitor_expr.csv.gz 828.0 Kb (ftp)(http) CSV
GSE108090_inhibitor_merged_replicates_expr.csv.gz 498.5 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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