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| Status |
Public on Dec 11, 2018 |
| Title |
Epigenetic control of genes and transposable elements [ATAC-seq] |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Epigenetic control is an elaborate system the cell uses to control aspects of cell type and gene control. Histones and DNA are chemically modified to signal epigenetic information as to whether a gene is active or inactive, and so maintain cell type stability. Whilst epigenetic control of genes has been explored, the control of the rest of the genome is less well explored. The bulk of DNA and chromatin consists of repetitive elements, not genes, and these TEs must be tightly regulated to provide structure and function for nearby genes and, ultimately, cell type control. In this project we explore the intereaction of epigenetic control factors, and inhibitors, and how perturbation of the epigenetic control system disrupts TE regulation inside embryonic stem cells.
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| Overall design |
We analyzed the transcriptome expression profiles (RNA-seq) and chromation accessibility (ATAC-seq) upon specific epigenetic perturbation
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| Contributor(s) |
He J, Hutchins AP |
| Citation(s) |
30604769 |
| |
| Submission date |
Dec 14, 2017 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Jiangping He |
| E-mail(s) |
he_jiangping@grmh-gdl.cn
|
| Organization name |
Guangzhou Institutes of Biomedicine and Health (GIBH), CAS
|
| Street address |
Kai yuan avenue 190
|
| City |
GuangZhou |
| ZIP/Postal code |
510530 |
| Country |
China |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (20)
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| This SubSeries is part of SuperSeries: |
| GSE108091 |
Epigenetic control of genes and transposable elements |
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| Relations |
| BioProject |
PRJNA422437 |
| SRA |
SRP126771 |
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