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Series GSE106920 Query DataSets for GSE106920
Status Public on Jun 30, 2020
Title Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer (RNA-Seq)
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Metastasis is the cause of death for 90% of cancer patients, but little is known about how cancer cells adapt to and colonize new tissue environments. Using clinical samples and primary/metastatic cell lines, we found metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program and gain a liver-specific gene transcription program as they metastasize in the liver. We revealed this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical and super-enhancers. Further, we identified FOXA2, a liver-specific transcription factor, plays a key role in this transcription reprogramming and the colonization of metastatic CRC cells in the liver. Notably, this transcription reprogramming is also observed in multiple cancer types. Our data demonstrate that epigenetically reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically.
Overall design Examination of 4 different histone modifications and transcriptome in 2 cell lines.
Contributor(s) Li YE, Teng S
Citation(s) 31811277
Submission date Nov 15, 2017
Last update date Sep 29, 2020
Contact name Yang Eric Li
Phone +1-8589222580
Organization name Tsinghua University
Department School of Life Sciences
Lab Zhi John Lu
Street address Room 2-110, Biotechnology Building, School of Life Sciences, Tsinghua University
City Beijing
State/province Beijing
ZIP/Postal code 100084
Country China
Platforms (1)
GPL18460 Illumina HiSeq 1500 (Homo sapiens)
Samples (8)
GSM2857631 SW480_RNAseq
GSM2857632 SW620_RNAseq
GSM2857633 SW620_shFOXA2_1_1
This SubSeries is part of SuperSeries:
GSE106923 Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer
BioProject PRJNA418656
SRA SRP125123

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106920_RAW.tar 4.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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