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Series GSE106241 Query DataSets for GSE106241
Status Public on Dec 16, 2018
Title Agilent 8x60K Custom Exon array of human temporal cortical tissue samples with varying degree of Alzheimer's Disease (AD)-related neurofibrillary pathology
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In this study, we coupled microarray-based transcriptomics and MS-based phosphoproteomics assay to determine mRNA, protein, and phosphopeptide expression levels from 71 autopsied temporal cortical samples, with varying degree of Alzheimer's Disease (AD)-related neurofibrillary pathology. With computational analysis, we identified disease-related transcript, protein and phosphopeptide expression patterns, associated with distinct biological processes and cell types.
 
Overall design 71 human temporal cortical tissue samples were divided into 7 groups based on Braak staging (degree of AD-related neurofibrillary pathology) indicating the degree of disease severity. From 60 of these samples, transcripts were identified by microarray analysis. Additionally, utilizing liquid chromatography tandem mass spectrometry (LC-MS/MS) phospho-proteomics, proteins and phosphopeptides were identified from 36 samples (Data found in PRIDE). Furthermore, APOE genotype, Alpha-, beta-, and gamma-secretase activity, and amyloid-beta 42 levels were determined from the tissue samples.
 
Contributor(s) Marttinen M, Paananen J
Citation(s) 30557660
Submission date Oct 26, 2017
Last update date Mar 22, 2019
Contact name Mikael Marttinen
E-mail(s) mikael.marttinen@uef.fi
Organization name University of Eastern Finland
Department Biomedicine
Street address Yliopistonranta 1E
City Kuopio
ZIP/Postal code 70210
Country Finland
 
Platforms (1)
GPL24170 Agilent-044312 Human 8x60K Custom Exon array (Probe Name version)
Samples (60)
GSM2832613 95096
GSM2832614 95097
GSM2832615 95218
Relations
BioProject PRJNA415984

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106241_Data_matrix_full.csv.gz 11.3 Mb (ftp)(http) CSV
GSE106241_RAW.tar 140.7 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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