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Series GSE106106 Query DataSets for GSE106106
Status Public on Dec 20, 2017
Title mRNA differencial expression data between scrambled siRNA-treated mice and HN1L siRNA-treated mice tumor samples
Organism Homo sapiens
Experiment type Expression profiling by array
Summary (HN1L) is a targetable breast cancer stem cell (BCSC) gene that is altered in 25% of whole breast cancer and significantly correlated with shorter overall or relapse-free survival in triple negative breast cancer (TNBC) patients. HN1L silencing reduced the population of BCSCs, inhibited tumor initiation, re-sensitized chemo-resistant tumors to docetaxel, and hindered cancer progression in multiple TNBC cell line derived xenografts.
We used microarray to compare mRNA expression profiles from PDX BCM2665 xenograft tumors with or without HN1L knockdown, to identify role of HN1L in regulating cancer stem cells.
Overall design mRNA arrays were performed on 10 snap-frozen tumor samples from scrambled siRNA-treated and HN1L siRNA-treated BCM2665 xenografts (5 samples from each treatment group). Differencial expression was performed to identifiy significantly differencially expressed mRNA and corresponding pathways.
Contributor(s) Chang JC, Wong S, Liu Y, Choi DS, Wong H, Cong Y, Sheng J
Citation(s) 29249663
Submission date Oct 24, 2017
Last update date Mar 25, 2019
Contact name Jenny Chang
Organization name Houston Methodist Hospital
Department Houston Methodist Cancer Center
Street address 6670 Bertner Ave.
City Houston
State/province TX
ZIP/Postal code 77030
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (10)
GSM2829792 tumor from scrambled siRNA-treated mouse #4817 [mRNA]
GSM2829793 tumor from scrambled siRNA-treated mouse #4819 [mRNA]
GSM2829794 tumor from scrambled siRNA-treated mouse #4989 [mRNA]
This SubSeries is part of SuperSeries:
GSE106200 RNA differencial expression data between scrambled siRNA-treated mice and HN1L siRNA-treated mice tumor samples
BioProject PRJNA415909

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE106106.txt.gz 17.6 Kb (ftp)(http) TXT
GSE106106_RAW.tar 48.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record

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