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Series GSE105794 Query DataSets for GSE105794
Status Public on Oct 24, 2017
Title miRNA expression data from adult mouse Prefrontal Cortex following high fat diet exposure (8 weeks, starting on PND28)
Platform organism synthetic construct
Sample organism Mus musculus
Experiment type Expression profiling by array
Summary High-fat diet (HFD) feeding during adolescence induces robust impairments in prefrontal-dependent cognition. Moreover, it also provokes multiple changes at the cellular and synaptic scales within the mPFC, suggesting that major transcriptional events are elicited by HFD during this maturational period. While it has been speculated that the nature of this transcriptional reprogramming may involve epigenetic effects, such as microRNA expression, this question to date remains unanswered. Here, we addressed this issue by performing unbiased genome-wide transcriptional profiling of miRNAs in the mouse mPFC following adolescent HFD.
We performed unbiased genome-wide transcriptional profiling of miRNAs in the mouse mPFC following adolescent HFD
Overall design C57BL/6N male where exposed to HFD or Low fat diet (LFD) for 8 weeks starting from PND28. (HFD:consisting of 60% of calories from fat; LFD 10% of calories from fat ). We then performed genome wide miRNA expression analyses, validations, behavioral analyses.
Contributor(s) Labouesse M, Richetto J, Cattaneo A
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Submission date Oct 23, 2017
Last update date Jan 24, 2018
Contact name Juliet Richetto
Organization name University of Zurich - Vetsuisse
Department Institute for Pharmacology and Toxicology
Street address Winterthurerstrasse 260
City Zurich
ZIP/Postal code 8057
Country Switzerland
Platforms (1)
GPL19117 [miRNA-4] Affymetrix Multispecies miRNA-4 Array
Samples (12)
GSM2828297 PFC LFD mice, biological replicate 1
GSM2828298 PFC LFD mice, biological replicate 2
GSM2828299 PFC LFD mice, biological replicate 3
BioProject PRJNA415430

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Supplementary file Size Download File type/resource
GSE105794_RAW.tar 10.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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