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Series GSE104926 Query DataSets for GSE104926
Status Public on Sep 27, 2018
Title RNA-seq of exosomes identifies lncRNA profiles that distinguish early-stage esophageal squamous cell carcinoma (ESCC) from non-malignant esophagitis
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary We report the application of RNA sequencing technology for high-throughput profiling of transcriptomes in plasma exosomes from early-stage ESCC and esophagitis. By analyzing over 95G of clean reads (depleted rRNA), we found that expression features of exosomal lncRNAs were distinct from that of exosomal mRNAs. We identified differentially expressed exosomal lncRNAs and mRNAs for ESCC, and esophagitis. We further analyzed the biological functions of differentially expressed lncRNAs using GO, KEGG, as well as knockdown assay with siRNAs. This study provides information for identifying cancer and non-malignant disease relevant exosomal lncRNAs through integrative analyses of RNA sequencing data.
Overall design Examination and comparison of lncRNAs and mRNAs in exosomes from ESCC, esophagitis, and healthy control, respectively.
Contributor(s) Zhai R
Citation(s) 32043367
Submission date Oct 13, 2017
Last update date Aug 11, 2021
Contact name Rihong Zhai
Phone +86 755 26919842
Organization name Shenzhen University School of Medicine
Street address 1066 Xueyuan Ave.
City Shenzhen
State/province Guangdong
ZIP/Postal code 518060
Country China
Platforms (1)
GPL21290 Illumina HiSeq 3000 (Homo sapiens)
Samples (18)
GSM2810102 Control 1
GSM2810103 Control 2
GSM2810104 Control 3
BioProject PRJNA414172
SRA SRP119895

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Supplementary file Size Download File type/resource
GSE104926_All_exosomal_lncRNAs_RPKMs.xls.gz 5.4 Mb (ftp)(http) XLS
GSE104926_All_exosomal_mRNAs_RPKMs.xls.gz 7.3 Mb (ftp)(http) XLS
GSE104926_Differential_exosomal_lncRNAs_RPKMs.xls.gz 99.6 Kb (ftp)(http) XLS
GSE104926_Differential_exosomal_mRNAs_RPKMs.xls.gz 337.3 Kb (ftp)(http) XLS
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