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Series GSE104891 Query DataSets for GSE104891
Status Public on Mar 12, 2019
Title Regulation of mesenchymal stem to transit amplifying cell transition in the continuously growing mouse incisor [Histone ChIP]
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Regulation of transit amplifying cell formation from self-renewing stem cell is fundamental process for cell replacement in a controlled way. Here we analyse the properties of a population of mesenchymal TACs in the continuously growing mouse incisor to identify key components of the molecular regulation that drives proliferation. We show that the polycomb repressive complex 1 acts as a global regulator of the TAC phenotype by its direct action on the expression of key cell cycle regulatory genes and also by regulating Wnt/b-catenin signalling activity. We also identify an essential requirement for TACs in maintaining the mesenchymal stem cells, indicative of a positive feedback mechanism.
Analysing the properties of mesenchymal transit amplifying cells population and identifing key components of the molecular regulation that drives proliferation.
 
Overall design Histone ChIPseq without input sample (SICER algorithm used for analysis does not reqire input sample)
 
Contributor(s) An Z, Akily B, Sabalic M, Zong G, Sharpe PT
Citation(s) 29874594
Submission date Oct 12, 2017
Last update date May 15, 2019
Contact name Paul T. Sharpe
Organization name King's College London
Department Centre for Craniofacial and Regenerative Biology
Lab Sharpe Lab
Street address Guy's hospitial
City London
State/province Please select one below:
ZIP/Postal code SE1 9RT
Country United Kingdom
 
Platforms (1)
GPL19057 Illumina NextSeq 500 (Mus musculus)
Samples (2)
GSM2809675 H3K4me3_ChIPSeq
GSM2809676 H3K27me3_ChIPSeq
This SubSeries is part of SuperSeries:
GSE104893 Regulation of mesenchymal stem to transit amplifying cell transition in the continuously growing mouse incisor
Relations
BioProject PRJNA414106
SRA SRP119853

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104891_000KKings_dentalpulp_SICER_genes.xlsx 4.4 Mb (ftp)(http) XLSX
GSE104891_000KKings_dentalpulp_SICER_ucsctracks.bed.gz 659.6 Kb (ftp)(http) BED
GSE104891_000KKings_dentalpulp_bigWig_URLs.txt.gz 312 b (ftp)(http) TXT
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Raw data are available in SRA
Processed data are available on Series record

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