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Series GSE103478 Query DataSets for GSE103478
Status Public on Sep 06, 2017
Title Caloric restriction affects small RNA expression in mouse hepatic mitochondria
Organism Mus musculus
Experiment type Non-coding RNA profiling by high throughput sequencing
Summary MicroRNAs (miRNAs) are crucial post-transcriptional regulators that extensively affect protein synthesis. Emerging evidence suggests the presence of miRNAs in mitochondria and important regulatory roles of miRNAs in mitochondrial translation. To investigate whether miRNAs are involved in the CR-induced mitochondrial translational changes, we used small RNA sequencing to profile miRNA expression in whole liver tissue as well as in liver mitochondria. The sequencing results revealed that the number of miRNAs identified in mitochondria was comparable to that found in the whole tissue.
Overall design We used small RNA sequencing to profile miRNA expression in ad libitum vs. calorie-restricted mouse liver tissue and in liver mitochondria.
Contributor(s) Zhang R, Liu D, Chen H, Wang X, Qu J
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Submission date Sep 05, 2017
Last update date Jul 25, 2021
Contact name De-Pei Liu
Phone 86-10-69156415
Organization name Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
Street address Dong Dan San Tiao 5, Dongcheng District
City Beijing
ZIP/Postal code 100005
Country China
Platforms (1)
GPL16417 Illumina MiSeq (Mus musculus)
Samples (8)
GSM2772114 AL total small RNA seq
GSM2772115 CR total small RNA seq
GSM2772116 AL mito small RNA seq rep1
BioProject PRJNA401785
SRA SRP117083

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Supplementary file Size Download File type/resource
GSE103478_RAW.tar 70.0 Kb (http)(custom) TAR (of TXT)
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Raw data are available in SRA
Processed data provided as supplementary file

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